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Frontiers in Neuroscience 2022
PubMed: 35620673
DOI: 10.3389/fnins.2022.802778 -
Applied & Translational Genomics Sep 2014The term "Translational Genomics" reflects both title and mission of this new journal. "Translational" has traditionally been understood as "applied research" or... (Review)
Review
The term "Translational Genomics" reflects both title and mission of this new journal. "Translational" has traditionally been understood as "applied research" or "development", different from or even opposed to "basic research". Recent scientific and societal developments have triggered a re-assessment of the connotation that "translational" and "basic" are either/or activities: translational research nowadays aims at feeding the best science into applications and solutions for human society. We therefore argue here basic science to be challenged and leveraged for its relevance to human health and societal benefits. This more recent approach and attitude are catalyzed by four trends or developments: evidence-based solutions; large-scale, high dimensional data; consumer/patient empowerment; and systems-level understanding.
PubMed: 27284502
DOI: 10.1016/j.atg.2014.05.001 -
Deutsches Arzteblatt International Apr 2009The choice of study type is an important aspect of the design of medical studies. The study design and consequent study type are major determinants of a study's...
BACKGROUND
The choice of study type is an important aspect of the design of medical studies. The study design and consequent study type are major determinants of a study's scientific quality and clinical value.
METHODS
This article describes the structured classification of studies into two types, primary and secondary, as well as a further subclassification of studies of primary type. This is done on the basis of a selective literature search concerning study types in medical research, in addition to the authors' own experience.
RESULTS
Three main areas of medical research can be distinguished by study type: basic (experimental), clinical, and epidemiological research. Furthermore, clinical and epidemiological studies can be further subclassified as either interventional or noninterventional.
CONCLUSIONS
The study type that can best answer the particular research question at hand must be determined not only on a purely scientific basis, but also in view of the available financial resources, staffing, and practical feasibility (organization, medical prerequisites, number of patients, etc.).
Topics: Biomedical Research; Clinical Trials as Topic; Germany; Periodicals as Topic; Research; Science
PubMed: 19547627
DOI: 10.3238/arztebl.2009.0262 -
Natural Products and Bioprospecting Feb 2017Recently, there has been a renewed interest in the natural-products-inspired drugs. Quebrachitol (QCT) is one of naturally occurring optically active cyclitols that has... (Review)
Review
Recently, there has been a renewed interest in the natural-products-inspired drugs. Quebrachitol (QCT) is one of naturally occurring optically active cyclitols that has now received considerable attention. Until the last decade, it came to be a starting point for the lead discovery. In this review, we had a discussion on the basic research of QCT, including its source, structure, properties, and the recent advances on its application. The biological activities and QCT-inspired leads that are potentially effective for treating human diseases were also discussed.
PubMed: 28132388
DOI: 10.1007/s13659-017-0120-3 -
Journal of the American Society of... Jan 2018
PubMed: 29093027
DOI: 10.1681/ASN.2017090965 -
Journal of Personalized Medicine Aug 2021The established contribution of genetic variation to drug response has the potential to improve drug efficacy and reduce drug toxicity [...].
The established contribution of genetic variation to drug response has the potential to improve drug efficacy and reduce drug toxicity [...].
PubMed: 34442444
DOI: 10.3390/jpm11080800 -
International Journal of Molecular... Dec 2022Celiac disease (CD) is an immune-mediated disorder triggered by dietary gluten intake in some genetically predisposed individuals; however, the additional... (Review)
Review
Celiac disease (CD) is an immune-mediated disorder triggered by dietary gluten intake in some genetically predisposed individuals; however, the additional non-HLA-related genetic factors implicated in CD immunopathogenesis are not well-defined. The role of the innate immune system in autoimmunity has emerged in the last few years. Genetic polymorphisms of some pattern-recognition receptors, including toll-like receptors (TLRs), have been associated with several autoimmune disorders. In this review, we summarize and discuss the evidence from basic research and clinical studies as regards the potential role of TLRs in CD immunopathogenesis. The evidence supporting the role of TLRs in CD immunopathogenesis is limited, especially in terms of basic research. However, differences in the expression and activation of TLRs between active CD patients from one side, and controls and treated CD patients from the other side, have been described in some clinical studies. Therefore, TLRs may be part of those non-HLA-related genetic factors implicated in CD etiopathogenesis, considering their potential role in the interaction between the host immune system and some environmental factors (including viral infections and gut microbiota), which are included in the list of candidate agents potentially contributing to the determination of CD risk in genetically predisposed individuals exposed to dietary gluten intake. Further basic research and clinical studies focused on TLRs in the context of CD and other gluten-related disorders are needed.
Topics: Humans; Celiac Disease; Toll-Like Receptors; Glutens; Autoimmunity; Immune System; Genetic Predisposition to Disease; Immunity, Innate
PubMed: 36613709
DOI: 10.3390/ijms24010265 -
Innovative Surgical Sciences Jun 2018
PubMed: 31579776
DOI: 10.1515/iss-2018-0019 -
International Journal of Molecular... Apr 2023Translational medicine is an interdisciplinary field that combines basic research findings with clinical practice to accelerate the development of new diagnostic tools,...
Translational medicine is an interdisciplinary field that combines basic research findings with clinical practice to accelerate the development of new diagnostic tools, therapies, and preventive strategies for human diseases [...].
Topics: Humans; Translational Research, Biomedical; Translational Science, Biomedical
PubMed: 37175431
DOI: 10.3390/ijms24097726 -
Frontiers in Microbiology 2023
PubMed: 37256056
DOI: 10.3389/fmicb.2023.1194926